How testosterone-aromatase derived estradiol transformation to 2-methoxy-17beta-estradiol can mitigate cell proliferation by promoting a senescent phenotype.DJGPhD. Authentic Biochemistry.8.DEC.21
- Author
- Dr Daniel J. Guerra
- Published
- Wed 08 Dec 2021
- Episode Link
- https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/episodes/How-testosterone-aromatase-derived-estradiol-transformation-to-2-methoxy-17beta-estradiol-can-mitigate-cell-proliferation-by-promoting-a-senescent-phenotype-DJGPhD--Authentic-Biochemistry-8-DEC-21-e1bepae
Besides 2-methoxy-17beta-estradiol, cell cycle arrest via chromatin deacetylation can mitigate cell proliferation by decreasing global transcription while promoting the expression of tumor suppressor genes like p16INK4a while DNA Damage Repair (DDR) from pro-inflammatory cytokine production from senescent cells and Th1 lymphocytes can inhibit commitment to mitosis and cytokinesis by generating the paracrine SASP paradigm.
Refs.
Am J Physiol Cell Physiol 2012;302:C1026-C1034
Steroids Volume 75, Issue 10, October 2010, Pages 625-631
Oncotarget. 2013 Oct; 4(10): 1552–1553
Cancer Metastasis Rev. 2020; 39(3): 681–709
