From Glucose to Triacylglycerol in the developing T lymphocyte. Dr Daniel J. Guerra. Authentic Biochemistry 21 December 2020
- Author
- Dr Daniel J. Guerra
- Published
- Wed 23 Dec 2020
- Episode Link
- https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/episodes/From-Glucose-to-Triacylglycerol-in-the-developing-T-lymphocyte--Dr-Daniel-J--Guerra--Authentic-Biochemistry-21-December-2020-eo5via
In this episode Dr Guerra provides a concise description of T lymphocytic fatty acid synthesis from glucose via cytosolic glycolysis, mitochondrialpyruvate dehydrogenase, pyruvate carboxylase, and citrate synthase and a return to the cytosol for ATP citrate lyase and the homodimeric polyprotein complex FAS to generate palmitoyl-ACP.
This ability of antigen-MHC Antigen Presenting Cell TCR - activated T lymphocytes to prepare for massive cytokine and chemokine expression requires a biochemical poise to use newly synthesized intracellular triacylglycerol to drive cellular exapnsion and effector-mediated immune responses.
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