Dr Guerra suggests targeting senescence as a means to alter the rate of aging is contrarion to healthy outcome because of derepression of tumorigenesis.
- Author
- Dr Daniel J. Guerra
- Published
- Tue 22 Sep 2020
- Episode Link
- https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/episodes/Dr-Guerra-suggests-targeting-senescence-as-a-means-to-alter-the-rate-of-aging-is-contrarion-to-healthy-outcome-because-of-derepression-of-tumorigenesis-ejvsmk
The human body is tempered by cellular fate paradigms that include senescence vs. proliferation during aging. A corruption in the senescnce associated secretory phenotype may be a proximal tareget to reduce aging morbidity but does it not open the door to oncogenesis and the potential for autoimmune disease?
Comput Struct Biotechnol J. 2019; 17: 1151–1161
Nat Med. 2017 Jun; 23(6): 775–781
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