Dr. Guerra presents: The CNS and the Immune System are linked to Recombination and the Epigenome. Lecture IV. 24.4.21 Authentic Biochemistry
- Author
- Dr Daniel J. Guerra
- Published
- Sat 24 Apr 2021
- Episode Link
- https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/episodes/Dr--Guerra-presents-The-CNS-and-the-Immune-System-are-linked-to-Recombination-and-the-Epigenome--Lecture-IV--24-4-21-Authentic-Biochemistry-evisiu
As an hypothetico-deduction, Dr. Guerra proposes that the Recombination Activating Gene-RAG System is a Potential Candidate in Age Associated Morbidity.
In conjunction with a neutral sphingomyelinase and the subsequent synthesis of diacylglycerol thence promoting activation of a PKC-Zeta, T cell receptor translocation and activation are obtained.
Prior RAG mediated recombination events in CNS-resident lymphocytes, associated microglia and neurons can lead to recombination event epigenomic ontologies that either promote or curtail a resident hyperimmune response leading to classical neurodegenerative diseases of the elderly.
References:
J. Biol. Chem. 1998;273:14550-14559
Frontiers in Immunology.2014. 5:100
Front Cell Dev Biol. 2019; 7: 226.
