Dr. Guerra explains the ID2 HLH pseudo transcriptional corridor in leukemia and aging. 11 November 2020

1.Id proteins are helix-loop-helix (HLH) proteins lacking the basic amino acid domain necessary to bind DNA.and therefore ID  functions in a dominant negative manner by sequestering ubiquitously expressed  or cell- restricted  basic HLH transcription factors: this results in effective blockade of transcription since ID causes a failure  of dimerized basic HLH proteins to bind DNA.

2. Id proteins  regulate transcription factors that are involved in developmental processes such as myogenesis, neurogenesis, bone morphogenesis, lymphopoiesis hematopoiesis, and myeloid differentiation

3. Id2−/− mice lack lymph nodes and Peyer's patches*,

*Peyer's patches are discrete masses of lymphatic tissue found throughout the ileum of the mammalian small intestine

Oncogene volume 22, pages1–9(2003)

PNAS January 15, 2019 116 (3) 890-899

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