DDR and the roles of Sirtuins and the NAD metabolic paradigm in aging. Published by Authentic Biochemistry Dr. Daniel J. Guerra 19 Oct 2020

The pineal endocrine hormone melatonin proximally decreasesIL-1β-induced MMP production by inhibiting Sirt1-dependent NAMPT and NFAT5 signaling in chondrocytes;  since autoinflammatory  Osteoarthritis (OA) is a degenerative joint (cartilage degradation) disease linked to human aging and Interleukin-1β  contributes to OA pathogenesis by enhancing oxidative stress and inflammation the role(s) of sirtuin and NAD+ metabolism is associated with aging morbidity while also being described in Double-Stranded Break (DBS) DNA Damage Repair (DDR), we have isolated and identified with distinction, pathobiochemical components of the human aging event ontology.

Oncotarget. 2017 Aug 22; 8(34): 55967–55983.

PLOS One .November 25, 2014https://doi.org/10.1371/journal.pone.0113939

Int J Mol Sci. 2019 Mar; 20(5): 1223.

eLife 2020;9:e55828 DOI: 10.7554/eLife.55828