Blocking cellular senescence may suppress autoimmune diseases and reactive oxygen mediated cell death but non-ironically promote oncogenesis and tumor development during ageing. DJGPhD. 06.DEC.21

Cell fate from Either ageing associated senescence to programmed cell death OR cell proliferation is finely tuned to the splice variant  expression of Cell Cycle dependent kinase inhibitors and the relative production of pro-inflammatory cytokines under the synchrony of DNA Damage Repair (DDR), telomerase expression decline, and the protective role of the Senescence Associated Secretory Phenotype (SASP).

Dr. Daniel J. Guerra. 06 Dec 2021 Authentic Biochemistry Productions

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EBioMedicine 2016 830-39DOI: (10.1016/j.ebiom.2016.04.017