Authentic Biochemistry Neuroimmune and Epigenetic Interactions in Aging III. DJGPhD 21.4.21
- Author
- Dr Daniel J. Guerra
- Published
- Wed 21 Apr 2021
- Episode Link
- https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/episodes/Authentic-Biochemistry-Neuroimmune-and-Epigenetic-Interactions-in-Aging-III--DJGPhD-21-4-21-evcl0l
Single-nucleotide polymorphisms and copy-number variations (CNV’s) result from genome wide chromosomal abnormalities including large deletions and duplications where the the immune system appears to play a major role in the accumulation of chromosomal variation.
Aging in humans may be linked to immune-mediated epigenomic epistasis as facilitated by Recombination Activating Gene proteins RAG1 & RAG2 that are canonically linked to V(D)J recombination of the T cell receptor and the B cell immunoglobulins.
- FEBS J. 2017 Jun; 284(11): 1590–1605.
