Aging results in corruption of T lymphocyte differentiation associated with chromatin instability and epithelial to mesenchymal transitions leading to the pre-cancerous state. DJGPhD 16.10.21
- Author
- Dr Daniel J. Guerra
- Published
- Sat 16 Oct 2021
- Episode Link
- https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/episodes/Aging-results-in-corruption-of-T-lymphocyte-differentiation-associated-with-chromatin-instability-and-epithelial-to-mesenchymal-transitions-leading-to-the-pre-cancerous-state--DJGPhD-16-10-21-e18solr
Chromatin instability leads to alterations in gene expression that re-directs cellular senescence by corruption of chemokine and cytokine signalling resulting in epithelial to mesenchymal transitions and the potential for metastatic cancer in the elderly .
As lymphocyte lineage's age these underlying pathobiochemical events are potentiated by hypo and hyper immune responses thus generating a downward reductio to misdirected hyperinflammatory states and the potential for autoimmune disease sequalae.
