EP088 - Serotonin Syndrome in a Bank Clerk

This podcast is based on clinical scenarios from the official AMC Handbook of Clinical Assessment published by the Australian Medical Council. All cases are used solely for study and discussion. We provide personal learning insights and clinical interpretations to support AMC candidates in developing their clinical reasoning skills. The AMC Handbook is the intellectual property of the Australian Medical Council. To access the official material, please visit the AMC website.

This medical case details the presentation and management of a 30-year-old patient experiencing nausea, headaches, and a "jittery" sensation. The core issue revolves around serotonin syndrome, a serious condition resulting from an excess of serotonin in the central nervous system, often due to drug interactions. Specifically, the patient's symptoms arose from the inadequate washout period between two different Selective Serotonin Reuptake Inhibitor (SSRI) medications: Prozac (fluoxetine) and Zoloft (sertraline). The case outlines the diagnostic process, emphasising the need to discontinue the offending medication and provide supportive care while acknowledging the importance of addressing the patient's underlying depression.

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