Is childhood cancer genetic?

Pediatric cancer and genetic testing. In this conversation, Sarah Scollon discusses the complexities of childhood cancer, particularly the genetic factors that may contribute to its development. She explains the differences between tumor and germline testing, the importance of identifying children at risk for hereditary cancer syndromes, and the evolving guidelines for genetic testing in pediatric oncology. The discussion also touches on the psychosocial aspects of genetic counseling, informed consent, and the implications of genetic testing for families. Sarah emphasizes the need for ongoing research and the importance of communication with families about genetic risks and testing options.

Key Takeaways:

• About 8 to 18 percent of kids with cancer have genetic mutations.


• Tumor testing focuses on mutations in the tumor itself.


• Germline testing looks at inherited genetic changes.


• Genetic testing can lead to tailored surveillance plans.


• Informed consent is crucial in genetic testing discussions.


• Cascade testing can benefit family members of affected children.


• The landscape of genetic testing is rapidly evolving.


• Access to care and psychosocial support are vital for families.

Sarah Scollon is an Assistant Professor in the Department of Pediatrics at Baylor College of Medicine (BCM) and lead genetic counselor for the Texas Children’s Cancer and Genomics Program. She has served in dual clinical and research roles across the course of her career. Ms. Scollon has had a longstanding dedication to the care of children and families affected by cancer. She is an advocate for the incorporation of genetic counseling into pediatric cancer care. She works to educate others on the role genomics and precision oncology can play in the care of patients with pediatric cancer and their families both from a clinical and psychosocial standpoint. Her research interests engage the overarching themes of (1) pediatric cancer predisposition and precision oncology (2) optimization of patient-provider communication and education and (3) adaptation of genetic counseling practice for implementation of evolving technologies for care of pediatric cancer patients.

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Here are more resources related to today’s topic:

• Sarah Scollon’s Contact Info and Published Papers


• Findageneticcounselor.org to search for a genetic counselor near you


• Pediatric Oncology Series- includes recommendations


• American Association for Cancer Research- Childhood Cancer Awareness page

Any inquiries on the podcast can be sent to [email protected]

Note that this podcast is for entertainment and education and is not intended to be a substitute for professional medical advice. Please consult your physician with any questions you may have regarding your health.

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