A Coffee with CompBio
Step into the world where algorithms meet biology! Hosts Lorena Pantano and Alex Bartlett, two dynamic women in science, unravel the complexities and curiosities of computational biology. Each episode, they break down complicated analyses, demystify big data approaches, and share real-world stories from their own bioinformatics research adventures. Whether you’re a seasoned bioinformatician or just bio-curious, Alex and Lorena's engaging banter, expert interviews, and practical tips will guide you through the fascinating process of turning raw biological data into meaningful scientific discoveries. Join them as they make computation in the life sciences accessible—and even a little bit fun!
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- Update frequency
- every 14 days
- Average duration
- 19 minutes
- Episodes
- 8
- Years Active
- 2025
The Spatial Transcriptomics Toolkit: Memory, Clustering, and Deconvolution
In this episode, Alex and Lorena tackle the computational challenges of spatial transcriptomics. Learn how BPCells can help you work with millions of cells without needing terabytes of RAM, discover …
A coffee with Katie Hughes - First hand experience on transitioning to a Product Manager role
Alex Barlett and Lorena Pantano welcome Katie Hughes, their first guest, to discuss her career transition from bioinformatics to product management. Katie shares her journey from studying genetics, w…
R You Doing It Right? Modern Best Practices in R
Alex and I dig into the tricks and tips that'll actually make your R code work better. We're talking about ditching those old habits we all picked up and switching to code that works better in 2025. …
Fast, Private, and Publish-Ready Spatial Transcriptomics App (Without Losing Your Mind)
In this episode, we journey through the real-life challenges of building interactive single cell spatial data visualizations for large projects. Lorena shares her recent adventure turning mountains o…
R Markdown: Because RNA-seq Code Shouldn't Be Wild-Type
Alex and Lorena discuss a large bulk RNA-seq project that yielded lasting changes to their group’s everyday bioinformatics practices via the creation of parameterized R Markdown code templates. In th…
The Thousand-Dollar Alignment
In this episode of A Coffee with CompBio, Lorena and Alex share the twists and turns of realizing their methylation data wasn’t what it seemed. From puzzlingly low mapping rates to unexpected cloud c…
Nine Samples and Zero Cells: A Week in the Life of Single-Cell Analysis
In our first episode, Alex and Lorena dive into the messy reality of processing single-cell RNA-seq data. What started as a simple QC project turned into a week-long journey across compute environmen…
About Us
In the introductory episode, Lorena and Alex introduce themselves and share how they got started in computational biology. They talk about their career paths, what drew them to bioinformatics, and so…